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Research on the use of vitamin B6 with autistic children began in the 1960s. In 1966 two British neurologists, A. F. Heeley and G. E. Roberts, reported that 11 of 19 autistic children excreted abnormal metabolites in their urine when given a tryptophan load test. Giving these children a single 30 mg tablet of vitamin B6 normalized their urine; however, no behavioral studies were done.
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